Table 2 GATA3 gene expression in relation to clinicopathological variables and ER-phosphorylation in ER-positive tumors

From: GATA3 and markers of epithelial-mesenchymal transition predict long-term benefit from tamoxifen in ER-positive breast cancer

 

GATA3 gene expression by tertiles (T)

T1

T2

T3

 

n (%)

n (%)

n (%)

p-valuea

Tamoxifen

Untreated

83 (35)

75 (31)

82 (34)

 

Treated

88 (32)

96 (35)

88 (32)

0.95

Tumor size

≤20 mm

137 (33)

139 (34)

138 (33)

 

≥20 mm

31 (34)

30 (33)

31 (34)

0.98

PgR

<10%

56 (37)

38 (25)

57 (38)

 

≥10%

104 (33)

115 (36)

98 (31)

0.76

HER2

Negative

146 (32)

151 (34)

153 (34)

 

Positive

18 (69)

4 (15)

4 (15)

0.00076 (−)

pERs167 nuclear

Negative

132 (35)

121 (32)

121 (32)

 

Positive

33 (29)

40 (35)

40 (35)

0.30

pERs305 nuclear

Negative

117 (39)

99 (33)

83 (28)

 

Positive

44 (25)

59 (33)

76 (42)

0.00014

  1. P-values for significant associations in bold. A significant negative association is indicated with a minus sign.
  2. aP-value from Spearman rank order correlation.