Table 3 GATA3 in association with epithelial and mesenchymal biomarkers in ER-positive breast cancer

From: GATA3 and markers of epithelial-mesenchymal transition predict long-term benefit from tamoxifen in ER-positive breast cancer

 

GATA3 mRNA n (%)

GATA3 protein n (%)

T1

T2

T3

p

Low

High

p

CDH1 (E-cadherin)

   

0.00020

  

0.10

T1

79 (39)

67 (32)

43 (24)

 

22 (15)

129 (85)

 

T2

57 (33)

60 (35)

54 (32)

 

18 (12)

132 (88)

 

T3

44 (27)

44 (27)

73 (45)

 

31 (22)

111 (78)

 

FOXA1

   

<0.00001

  

0.43

T1

71 (54)

43 (33)

18 (14)

 

20 (18)

90 (82)

 

T2

61 (33)

64 (34)

62 (33)

 

27 (16)

141 (84)

 

T3

39 (20)

64 (33)

90 (47)

 

24 (15)

141 (85)

 

NOTCH3

   

0.00078

  

0.83

T1

72 (39)

59 (32)

54 (29)

 

27 (16)

138 (84)

 

T2

63 (36)

64 (37)

47 (27)

 

24 (16)

124 (84)

 

T3

36 (24)

48 (31)

69 (45)

 

20 (15)

110 (85)

 

ACTA2 (α-sma)

   

0.00025 (−)

  

0.0010 (−)

T1

38 (23)

56 (34)

71 (43)

 

15 (10)

129 (90)

 

T2

66 (38)

52 (30)

54 (31)

 

20 (13)

132 (87)

 

T3

67 (38)

63 (36)

45 (26)

 

36 (24)

111 (76)

 

CDH2 (N-cadherin)

   

<0.00001 (−)

  

0.023 (−)

T1

30 (18)

54 (32)

84 (50)

 

18 (12)

130 (88)

 

T2

55 (32)

55 (32)

61 (36)

 

21 (14)

128 (86)

 

T3

86 (50)

62 (36)

25 (14)

 

32 (22)

114 (78)

 

SNAI1 (Snail)

   

<0.00001 (−)

  

0.0042 (−)

T1

42 (23)

57 (32)

81 (45)

 

16 (10)

142 (90)

 

T2

61 (35)

63 (36)

50 (29)

 

25 (17)

126 (83)

 

T3

68 (43)

51 (32)

39 (25)

 

30 (22)

104 (78)

 

TWIST1

   

<0.00001 (−)

  

0.98

T1

27 (16)

55 (34)

82 (50)

 

22 (15)

123 (85)

 

T2

62 (35)

63 (36)

50 (29)

 

26 (18)

122 (82)

 

T3

82 (47)

51 (31)

38 (22)

 

23 (15)

127 (85)

 

VIM (Vimentin)

   

0.00010 (−)

  

0.74

T1

44 (25)

50 (29)

79 (46)

 

21 (13)

135 (87)

 

T2

60 (35)

65 (38)

47 (27)

 

30 (20)

119 (80)

 

T3

67 (40)

56 (34)

44 (26)

 

20 (14)

118 (86)

 
  1. P-values for significant associations in bold. A significant negative association is indicated with a minus sign.