Fig. 5: SPP1+ macrophages and CD8T/CD4T are spatially colocalized in TIL-high HR+ breast cancer.
From: SPP1+ macrophages in HR+ breast cancer are associated with tumor-infiltrating lymphocytes
a H&E image of the TIL-low (CID4290) tissue section analyzed using VISIUM. b Classification of the VISIUM public dataset23. c H&E image of the TIL-high (CID4535) tissue section analyzed using VISIUM. d Classification of the VISIUM public dataset. e Signature score of mono/macro, SPP1+macro, CD8T, and CD4T in TIL-low (CID4290). f Signature score of mono/macro, SPP1+macro, CD8T, and CD4T in TIL-high (CID4535). g Correlation of signature scores between SPP1+macro and CD8T (left), and between SPP1+macro and CD4T (right) presented as Spearman’s correlation coefficient. SPP1+macro SPP1+ macrophages, CD8T CD8+ T-cells, CD4T CD4+ T-cells, TIL tumor-infiltrating lymphocytes.
