Fig. 1: Schematic diagram of the study design and ctDNA analysis workflow. | npj Breast Cancer

Fig. 1: Schematic diagram of the study design and ctDNA analysis workflow.

From: Personalized mutation tracking in circulating-tumor DNA predicts recurrence in patients with high-risk early breast cancer

Fig. 1: Schematic diagram of the study design and ctDNA analysis workflow.The alternative text for this image may have been generated using AI.

A Diagram showing the number of breast cancer patients recruited and followed up in the study, as well as the number of tissue and serial plasma samples collected for analysis. B For each patient, paired tumor FFPE and WBC DNA samples were sequenced to identify tumor-specific mutations in 95 cancer-associated genes. The top 1–9 mutations were used to detect ctDNA in serial plasma samples by bespoke multiplex PCR and ultra-deep sequencing.

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