Fig. 4: Genomic landscape of POLH and RAD51 mutated breast tumors. | npj Breast Cancer

Fig. 4: Genomic landscape of POLH and RAD51 mutated breast tumors.

From: Germline variants of the POLH and RAD51 genes are candidate variants associated with risk of hormone receptor-negative young-onset breast cancer

Fig. 4: Genomic landscape of POLH and RAD51 mutated breast tumors.

Oncogenic or pathogenic somatic mutations, and mutational signatures identified in 12 tumors from patients carrying POLH (n = 4) or RAD51 (n = 8) variants. The phenobar provides information on clinicopathological features, HRDetect, and CHORD. SBS single base substitution, IDC invasive ductal carcinoma, HR hormone receptor, TN triplenegative, ER estrogen-receptor, HG histological grade.

Back to article page