Table 2 Diagnostic performance of baseline ctDNA detection compared to three clinical endpoints—residual cancer burden (RCB 0–2 vs. 3), ultrasound response (US responder vs. non‑responder) and cell‑cycle arrest (CCCA; Ki‑67 ≤ 2.7% vs. > 2.7%)—expressed as sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV)
From: Personalized ctDNA detection and genomic profiling in the NeoRHEA Study
Clinical outcome | Sensitivity | specificity | PPV | NPV |
|---|---|---|---|---|
CCCA | 0.429 | 0.465 | 0.207 | 0.714 |
RCB class | 0.760 | 0.549 | 0.452 | 0.824 |
Ultrasound | 0.528 | 0.425 | 0.452 | 0.500 |