Table 2 Diagnostic performance of baseline ctDNA detection compared to three clinical endpoints—residual cancer burden (RCB 0–2 vs. 3), ultrasound response (US responder vs. non‑responder) and cell‑cycle arrest (CCCA; Ki‑67 ≤ 2.7% vs. > 2.7%)—expressed as sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV)

From: Personalized ctDNA detection and genomic profiling in the NeoRHEA Study

Clinical outcome

Sensitivity

specificity

PPV

NPV

CCCA

0.429

0.465

0.207

0.714

RCB class

0.760

0.549

0.452

0.824

Ultrasound

0.528

0.425

0.452

0.500