Table 1 Univariate and multivariate Cox proportional hazards regression analyses of the association of variables with DFS in the training cohort
From: Prognostic value of nuclear features based on tumor-associated collagen signatures in breast cancer
Variable | Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|---|
HR | (95%CI) | P Value | HR | (95%CI) | P Value | |||
Age | ||||||||
>50 vs ≤50 | 1.156 | 0.831 | 1.610 | 0.389 | NA | NA | ||
Molecular subtype | ||||||||
Luminal B vs Luminal A | 1.995 | 1.218 | 3.269 | 0.006 | NA | NA | ||
HER2-enriched vs Luminal A | 1.754 | 0.974 | 3.158 | 0.061 | NA | NA | ||
Triple-negative vs Luminal A | 1.691 | 0.917 | 3.121 | 0.093 | NA | NA | ||
Tumor size | ||||||||
2–5 cm vs ≤ 2 cm | 1.616 | 1.120 | 2.331 | 0.010 | 1.538 | 1.055 | 2.243 | 0.025 |
≥5 cm vs ≤2 cm | 3.364 | 1.868 | 6.059 | <0.0001 | 1.835 | 0.971 | 3.468 | 0.062 |
Nodal status | ||||||||
1–3 vs 0 | 1.518 | 0.951 | 2.425 | 0.080 | 1.278 | 0.780 | 2.093 | 0.330 |
≥4 vs 0 | 3.430 | 2.355 | 4.997 | <0.0001 | 1.746 | 1.146 | 2.661 | 0.010 |
Clinical stage | ||||||||
Ⅱ vs Ⅰ | 1.642 | 0.991 | 2.718 | 0.054 | NA | NA | ||
Ⅲ vs Ⅰ | 4.131 | 2.523 | 6.765 | <0.0001 | NA | NA | ||
Histological grade | ||||||||
G2 vs G1 | 1.249 | 0.755 | 2.065 | 0.386 | 0.934 | 0.557 | 1.567 | 0.797 |
G3 vs G1 | 1.520 | 0.890 | 2.595 | 0.125 | 1.559 | 0.902 | 2.696 | 0.112 |
Chemotherapy | ||||||||
No vs Yes | 0.533 | 0.321 | 0.886 | 0.015 | 0.526 | 0.307 | 0.903 | 0.020 |
Radiation therapy | ||||||||
No vs Yes | 1.454 | 1.039 | 2.036 | 0.029 | NA | NA | ||
TACS -score | 2.890 | 2.410 | 3.466 | <0.0001 | 2.115 | 1.717 | 2.606 | <0.0001 |
TCMF1-score | 3.667 | 2.716 | 4.953 | <0.0001 | 1.861 | 1.354 | 2.557 | 0.00013 |
TCMF2-score | 4.187 | 3.164 | 5.540 | <0.0001 | 2.192 | 1.587 | 3.029 | <0.0001 |
