Table 1 Human studies on NSW and oxidative stress
From: Night shift work and breast cancer: from etiopathology to precision risk analysis
NSW Effect | Parameter(s) | Outcome | Year | Ref. |
|---|---|---|---|---|
↑ Oxidative DNA damage | Urinary 8-OH-dG | ↑ 8-OH-dG | 2001 | |
↑ Oxidative DNA damage linked to stress/depression (females) | Urinary 8-OH-dG | ↑ 8-OH-dG | 2008 | |
↑ Oxidative stress | Erythrocyte SOD activity, plasma MDA | ↑ SOD, ↑ MDA | 2008 | |
↓ Antioxidant capacity | Plasma total antioxidant capacity (TAC) | ↓ TAC | 2008 | |
↑ Oxidative stress | Serum TOS, OSI; ↓ TAS | ↑ TOS, ↑ OSI, ↓ TAS | 2010 | |
↑ Oxidative stress/burnout | Serum SOD1, MDA | ↑ SOD1, ↑ MDA | 2011 | |
↑ Oxidative stress during shifts | Serum TAS, TOS, OSI | ↓ TAS, ↑ TOS, ↑ OSI | 2012 | |
Altered antioxidant response (menopause-dependent) | Erythrocyte/plasma GPx | ↑ GPx (pre-M), ↓ GPx (post-M) | 2013 | |
No overall difference; possible compensatory effect | Plasma TAC, TOS, OSI | ↔ OS markers; TAC↔cognition | 2013 | |
Association with mild depression | Plasma TAC, MDA | ↓ TAC (depressed), ↔ MDA | 2014 | |
↓ DNA repair capacity | OGG1 gene expression | ↓ OGG1 | 2015 | |
Circadian variation in oxidative stress | Urinary 8-OH-dG | ↑ 8-OH-dG (day sleep vs night sleep) | 2016 | |
Impaired repair under melatonin suppression | Urinary 8-OH-dG | ↑ 8-OH-dG (night work vs night sleep) | 2017 | |
↑ Lipid peroxidation | Urinary 8-isoprostane | ↑ 8-isoP | 2017 | |
No light effect on oxidative markers | Salivary antioxidant capacity, thiols, CAT | ↔ parameters | 2018 | |
↑ DNA damage, ↓ repair genes | DNA damage (Comet assay), OGG1, ERCC1, XRCC1 expression | ↑ DNA damage, ↓ repair | 2019 | |
↔ Oxidative stress | Serum TOS, TAS | ↔ TOS/TAS | 2021 | |
↑ Endothelial oxidative stress after sleep restriction | Endothelial OS markers | ↑ OS, no ↑ antioxidants | 2023 | |
↑ Oxidative DNA damage persisting post-shift | Serum and urinary 8-OH-dG | ↑ 8-OH-dG (during and post NSW) | 2023 | |
↑ DNA repair during melatonin supplementation | Urinary 8-OH-dG | ↑ 8-OH-dG (day sleep), ↔ night shift | 2024 | |
↑ Baseline OS; improved with antioxidants | Serum D-ROMs | ↑ D-ROMs (baseline), ↓ after supplement | 2025 |
