Table 3 Human studies on NSW and inflammation
From: Night shift work and breast cancer: from etiopathology to precision risk analysis
NSW Effect | Parameter(s) | Outcome | Year | Ref. |
|---|---|---|---|---|
Poor sleep quality linked to elevated WBC rather than NSW itself | WBC (blood) | ↑ Systemic inflammation (sleep-mediated) | 2007 | |
Circadian disruption induces leukocytosis | Total leukocytes (blood) | ↑ Systemic inflammation | 2007 | |
No sustained inflammatory changes with rotational NSW | CRP, ILs, immune cell profile (blood) | ↔ No significant effect | 2011 | |
Multi-shift work increases CRP and WBC (reversible after cessation) | CRP, WBC (blood) | ↑ Mild systemic inflammation | 2011 | |
Elevated IL-6, CRP, WBC, neutrophils, lymphocytes, platelets | Multiple inflammatory markers (blood) | ↑ Systemic inflammation | 2011 | |
Higher hs-CRP and leukocyte count vs. day workers | hs-CRP, WBC (blood) | ↑ Systemic inflammation | 2016 | |
Circadian misalignment amplifies alcohol-induced inflammation | LBP, LPS, IL-6 (blood) | ↑ Basal inflammation, loss of rhythmicity | 2016 | |
NSW increases CRP and monocytes independent of CVD risks | CRP, monocytes (blood) | ↑ Systemic inflammation | 2017 | |
Night-only work elevates IL-6 but not hs-CRP | IL-6, hs-CRP (blood) | ↑ IL-6; ↔ hs-CRP | 2018 | |
Disrupted circadian variation in IL-6, partial for TNF/IL-1β | IL-6, TNF, IL-1β (saliva) | Altered cytokine rhythmicity | 2019 | |
CRP not elevated by NSW alone, but amplifies pain risk | CRP (blood) | ↔ CRP; ↑ Pain risk (synergistic) | 2021 | |
Increased leukocytes, hs-CRP, and differential counts | hs-CRP, WBC, neutrophils, lymphocytes, monocytes (blood) | ↑ Systemic inflammation | 2022 | |
Male NSW workers show higher GlycA (BMI-related) | GlycA (serum) | ↑ Low-grade inflammation | 2022 | |
NSW elevates WBC, LBP, TNF-α, IL-10; impairs cytokine response | WBC, LBP, TNF-α, IL-10 (blood) | ↑ Low-grade inflammation; ↓ cytokine responsiveness | 2023 | |
NSW and poor sleep ↑ BP, correlated with CRP, WBC, neutrophils | CRP, WBC, neutrophils (blood); BP | ↑ Low-grade inflammation, ↑ BP | 2023 | |
Elevated hs-CRP and TLC; predictors include NSW, age, BMI | hs-CRP, TLC (blood) | ↑ Systemic inflammation | 2024 | |
Low-grade inflammation mediates IBS risk (INFLA-score) | INFLA-score (5 biomarkers, plasma) | ↑ IBS risk | 2024 | |
NSW increases psoriasis severity and IL-8 | IL-8 (blood); psoriasis index | ↑ Chronic inflammation | 2024 | |
NSW ↑ CAR and NLR vs. day workers | CAR, NLR (blood) | ↑ Chronic low-grade inflammation | 2025 | |
NSW activates innate immune/inflammatory pathways (TLR/MyD88) | IL-1β, IL-2, IL-6, IFN-γ, CSF2 (blood) | ↑ Cytokine activation | 2025 | |
NSW ↑ INFLA-score (CRP, PLT, WBC, NLR) mediating IBS risk | INFLA-score (blood) | ↑ Low-grade inflammation; ↑ IBS risk | 2025 |
