Fig. 2: Multivariate analysis using Cox-Proportional Regression Model in pre-treatment specimens identifies ABCC1 as highly associated with T-DXd associated overall survival.
Expression level was treated as a continuous variable in the discovery work. a Hazard ratios are indicated by the circles, with upper and lower 95% confidence intervals represented by the whiskers. Statistical significance (log10 FDR-adjusted p-value) is indicated by the size of the circles, with larger circles indicating greater significance. Kaplan–Meier evaluation of ABCC1 (b), and ERBB2 (c) expression quartiles (Q4: highest expression, Q1: lowest expression) and association with T-DXd-specific overall survival. OS was calculated from start of treatment with T-DXd to last patient contact using insurance claims data. p value was calculated using log-rank test.
