Fig. 3: HER2 status conversion between core needle biopsy (CNB) and surgical excision specimens (SEB). | npj Breast Cancer

Fig. 3: HER2 status conversion between core needle biopsy (CNB) and surgical excision specimens (SEB).

From: Illuminating the clinicopathological and genomic landscape of HER2-null, ultralow, and low breast cancers: insights into diagnostic discordance between biopsy and surgical excision

Fig. 3: HER2 status conversion between core needle biopsy (CNB) and surgical excision specimens (SEB).

A–F Reprehensive images showing the conversion of HER2 status from CNB to SEB. G Density plot illustrating the percentage of HER2 positive tumor cells in 32 CNB slides with HER2-ultralow status, categorized by the HER2 immunohistochemistry (IHC) status of the corresponding SEB. H Density plot showing the percentage of HER2 - positive tumor cells in 474 CNB slides with HER2-low status, classified according to the HER2 IHC status of the respective SEB. All *p < 0.05, **p < 0.01, ***p < 0.001, n.s. not significant.

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