Table 3 Univariate and multivariate Fine-Gray regression analyses of BCI in the NCR cohort

From: Validation of minimal risk of recurrence classification by the Breast Cancer Index in early stage breast cancer

Variable

Univariate Analysis

Multivariate Analysis

(s)HR (95% CI)

P

(s)HR (95% CI)

P

NCR

 Agea

0.73 (0.50–1.06)

0.10

0.65 (0.42–0.99)

0.05

 Tumor size ( >20 mm vs ≤20 mm)

1.46 (0.95–2.26)

0.09

1.58 (0.95–2.65)

0.08

 Tumor grade (G2/G3 vs G1)

0.99 (0.59–1.66)

0.98

0.78 (0.45–1.35)

0.37

 Treatment (tamoxifen vs AI/sequential)

1.09 (0.69-1.71)

0.72

1.13 (0.72-1.81)

0.58

 BCIb

3.63 (2.05–6.44)

<0.001

3.42 (1.87–6.26)

<0.001

TEAM

 Agea

1.33 (1.03–1.71)

0.03

1.30 (0.99–1.70)

0.05

 Tumor size (>20 mm vs ≤20 mm)

1.91 (1.26–2.90)

0.003

1.66 (1.06–2.58)

0.03

 Tumor grade (G2/G3 vs G1)

0.85 (0.31–2.33)

0.76

0.50 (0.17–1.42)

0.19

 Treatment (tamoxifen vs exemestane)

0.99 (0.66–1.48)

0.94

1.08 (0.71–1.65)

0.72

 BCIb

7.81 (4.30–14.18)

<0.001

7.49 (3.97–14.11)

<0.001

  1. BCI Breast Cancer Index, G1 tumor grade 1, NCR Netherlands Cancer Registry, sHR subdistribution hazard ratio, AI Aromatase Inhibitor, TEAM Tamoxifen and Exemestane Adjuvant Multinational trial.
  2. aAge was analyzed in 10-year increments; in the NCR cohort, all patients were at least 70 years old. bBCI was analyzed as a continuous variable with 5-unit increments.