Fig. 1: Schedule of questionnaires and Comprehensive Geriatric Assessment (for the elderly subgroup) administered to study participants.

Adult female patients ( ≥ 21 years) scheduled to receive neoadjuvant chemotherapy or endocrine therapy were enrolled in the study. Participants completed patient-reported outcome surveys at three predefined time points during treatment. All participants completed the Functional Assessment of Cancer Therapy–Breast (FACT-B). Age-specific instruments were additionally administered: participants younger than 40 years completed the Body Image Scale, Dyadic Adjustment Scale–4 (DAS-4), and Female Sexual Function Index (FSFI), while participants older than 65 years completed health outcomes assessment tools.