Fig. 2: Diagram of patient flow through study.

A total of 241 patients were recruited, 6 were excluded due to stage IV disease diagnosed afterrecruitment. Of the 235 patients, 33 (15%) were young women aged ≤40 years, 134 (57%) were aged 41-64 years and 68 (29%) were older patients aged 65 years or over. All patients enrolled were requested to complete the FACT-B questionnaire at three timepoints with subgroups of patients (young women and older women) identified to complete additional questionnaires as statedinthe study design.