Fig. 1: Diagrams illustrate sampling and resolution for HAADF, chemical, and multimodal tomography.
From: Optimal 3D chemical imaging with multimodal electron tomography

3D reconstructions of CoO/CuO nanocube cluster decorated with Au nanoparticles are shown in (a–c). a HAADF reconstruction: High-resolution morphology but poor chemical discernment. b Chemical reconstruction: Easily discernible chemistry but poor resolution. c Fused MM-ET reconstruction: High-resolution morphology for each chemistry. d HAADF sampling: High-count elastic signals allow for many projections. High-resolution reconstructions possible due to fine sampling. Experimental limitations create a missing wedge of information. e Chemical sampling: Sparse inelastic signals lead to fewer projections and low resolution. f Fused MM-ET sampling: Combines elastic (HAADF) and chemical projections for high sampling, improved chemical specificity, and superior accuracy. Simulated dataset modified from Padgett et al.44.