Fig. 4: KDDANet provided novel molecular insights on KDDAs related to cancer.
From: Genome-wide discovery of hidden genes mediating known drug-disease association using KDDANet
a KDDANet resulting subnetwork mediating sotalol (DB00489)-prostate cancer (176807) association. b Top ten enriched KEGG terms of subnetwork genes mediating sotalol-prostate cancer association. c Gene expression-based survival analysis for CASP2, SPARC, and GRB2 in patients with prostate cancer, obtained by GEPIA online analysis (http://gepia.cancer-pku.cn/about.html). d KDDANet gene subnetwork mediating nebularine (DB04440)-lung cancer (211980) association. e Top ten enriched KEGG terms of subnetwork genes mediating nebularine-lung cancer association. f Gene expression-based survival analysis for BYSL and BOP1 in patients with TCGA LUAD lung cancer obtained by GEPIA online analysis (http://gepia.cancer-pku.cn/about.html) and their expression levels in lung cancer tumor samples and adjacent normal tissue samples, ***p value < 0.001, calculated by Wilcox signed rank test. In the subnetworks, the size of a gene node was proportional to its network degree; the thickness of a network edge was proportional to its flow amount.
