Fig. 1: Dynamic retinal vessel and static retinal vessel parameters in Fabry disease patients compared to healthy controls.

Violin plots of DVA parameters venular flicker-induced dilation (vFID: FD, n = 56; HC, n = 60; a) and arteriolar flicker-induced dilation (aFID: FD, n = 55; HC, n = 60; b) and SVA parameters CRVE; (c), CRAE; (d), and AVR; (e all n = 60) in age- and gender-matched Fabry patients (red) and healthy controls (blue). Boxplots display values as the median (line) and mean (green square). The Wilcoxon rank-sum test was used for non-parametric distributions, and the Student’s t-test was used for parametric distributions. Statistical significance is indicated as follows: *p < 0.05; **p < 0.01; ***p < 0.001. ROC curves for CRAE, AVR and vFID and their AUCs and 95% confidence intervals (CI) are shown (f). g shows representative fundus images of a Fabry disease patient and a healthy control, with semi-automatically labeled retinal arterioles and venules. Vessel calibers were measured one disc diameter away from the optic disc to derive the respective SVA parameters: CRAE, CRVE, and AVR. This figure was created with Affinity Publisher (Version 2.5.5).