Fig. 5: Static retinal vessel parameters, LysoGb3 and cardiac laboratory values in FD patients with and without a potential cardiac GLA gene variant. | npj Genomic Medicine

Fig. 5: Static retinal vessel parameters, LysoGb3 and cardiac laboratory values in FD patients with and without a potential cardiac GLA gene variant.

From: Endothelial dysfunction in Fabry disease: retinal biomarkers link cardiac GLA gene variants with chronic inflammation

Fig. 5

Boxplot of CRAE (a), AVR (b) and CRVE (c; all n = 60), LysoGb3 (d; n = 63), and laboratory parameters NT-proBNP (e; n = 38) and hsTnT (f; n = 38) between FD patients with a potential cardiac variant (red, n = 20) and FD patients with other GLA gene variants (blue, n = 43). LysoGb3, hsTnT and NT-proBNP were log-transformed. Boxplot displays values as median (line) and mean (green square). The Wilcoxon rank-sum test was used for non-parametric distributions, and the Student´s t-test was used for parametric distributions. * p < 0.05; **p < 0.01; ***p < 0.001. ROC curves for distinguishing gene variants are shown for CRAE, LysoGb3, NT-proBNP and hsTnT and their AUCs and 95% confidence intervals (CI) are shown (g).

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