Fig. 2: Relationships between relative E. faecalis abundance or relative tyrDC gene abundance and Cmax of levodopa/Cmax of carbidopa.

The ratio of the Cmax of levodopa to that of carbidopa showed significant negative correlations with relative E. faecalis abundance (r = –0.517, p = 0.018) (a) and relative tyrDC gene abundance (r = –0.612, p = 0.004) (b). Cmax maximum plasma concentration, E. faecalis Enterococcus faecalis, tyrDC tyrosine decarboxylase.