Fig. 5: EV-miRNAs are differentially expressed in biofluids of rotenone-treated rat models of PD. | npj Parkinson's Disease

Fig. 5: EV-miRNAs are differentially expressed in biofluids of rotenone-treated rat models of PD.

From: Rotenone induced acute miRNA alterations in extracellular vesicles produce mitochondrial dysfunction and cell death

Fig. 5: EV-miRNAs are differentially expressed in biofluids of rotenone-treated rat models of PD.

Acute rotenone toxicity was administered to young adult male Sprague-Dawley rats of 3 months of age at a concentration of 3 mg/kg for 8 and 24 h. Biofluids were subsequently collected from the rats post-euthanasia and EVs were isolated from the biofluids. The differential expression of EV-miRNAs in the (i) CSF and (ii) serum were determined by RT-qPCR. Asterisk (*), (**), (***), and (****) indicates values statistically significant from control; p value <0.05, <0.01, <0.001, and <0.0001 (respectively), SEM of ten independent experiments, data were analyzed using one-way ANOVA, followed by Dunnett’s multiple comparisons test.

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