Fig. 6: GO and KEGG analysis of astrocytes. | npj Parkinson's Disease

Fig. 6: GO and KEGG analysis of astrocytes.

From: Oligodendrocyte-astrocyte crosstalk in Parkinson’s disease mediates neuronal ferroptosis via the FGF signaling pathway

Fig. 6: GO and KEGG analysis of astrocytes.

A The volcano plot shows the Top 20 significantly upregulated/downregulated genes in oligodendrocytes in the PD group compared to the Ctrl group, with red representing upregulated genes and blue representing downregulated genes. B Results of the GO enrichment analysis. The results indicate that oligodendrocytes in PD also exhibit mitochondrial function enrichment similar to that observed in astrocytes. C Results of the KEGG enrichment analysis. In addition to the oxidative phosphorylation functional enrichment observed in astrocytes, oligodendrocytes also show functional enrichment of ferroptosis-related genes, indicating the presence of ferroptosis processes in oligodendrocytes in PD.

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