Fig. 1: Characteristics of SAR446159. | npj Parkinson's Disease

Fig. 1: Characteristics of SAR446159.

From: A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies

Fig. 1: Characteristics of SAR446159.

A Schematic diagram of SAR446159 and its mechanism of action. Images were generated with the assistance of Biorender. B The structure of α-Syn, showing the N-terminal (green) amphipathic region, the hydrophobic NAC (blue) region, and the acidic C-terminal (red) region (PDB: 1XQ8). C Sensograms of SAR446159 and 1E4 binding to monomeric and aggregated α-Syn.

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