Fig. 3: PFF blocking with SAR446159. | npj Parkinson's Disease

Fig. 3: PFF blocking with SAR446159.

From: A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies

Fig. 3: PFF blocking with SAR446159.

A Human iPSC-derived dopaminergic neurons or human microglia treated with α-Syn PFFs conjugated to pHrodo (5 μg/mL), with (+ SAR 10 μg/mL) or without SAR446159 (No SAR). The data were quantified at 24 h and normalized for relative confluence. B Mouse cortical neuron survival following high-dose PFF treatment. One-way ANOVA, followed by Dunnett’s multiple comparison’s test. C Cytokine secretion from human iPSC-derived dopaminergic neuron-astrocyte-microglia tricultures following treatment with α-Syn PFFs with or without antibodies. PFF = 10 μg/ml, antibodies = 10 μg/ml. One-way ANOVA, Sidak correction for multiple comparisons test. Error bars represent the mean ± S.D.

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