Table 3 NHP PK parameters

From: A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies

  

1E4

SAR446159

  

(mg/kg)

(mg/kg)

  

30

100

11.7

35.1

117

 

Unit

     

Serum AUClast

hr × mg/mL

80.3

336

31.7

77.6

458

CSF AUClast

hr × mg/mL

0.10

0.32

0.14

0.31

0.95

Brain AUClast

hr × mg/mL

0.01

0.07

0.06

0.20

0.77

CSF AUClast/Serum AUClast

%

0.12

0.09

0.44

0.40

0.21

Brain AUClast/Serum AUClast

%

0.02

0.02

0.18

0.26

0.17

  1. AUC0-τ values estimated from non-compartmental analysis of mean serum, CSF, and brain profiles following an i.v. bolus administration of 1E4 and SAR446159 to naïve NHPs. AUClast represents area under the plasma concentration time curve from time zero to the last measurement.
  2. AUClast: area under the drug concentration time curve from time = 0 to last measured concentration.
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