Fig. 5: Single-cell transcriptomic profiling of peripheral blood immune cells from HC and PD patients. | npj Parkinson's Disease

Fig. 5: Single-cell transcriptomic profiling of peripheral blood immune cells from HC and PD patients.

From: Peripheral immune cell-specific genes in Parkinson’s disease uncovered by multi-omics with therapeutic implications

Fig. 5: Single-cell transcriptomic profiling of peripheral blood immune cells from HC and PD patients.The alternative text for this image may have been generated using AI.

A UMAP projection of all cells from six samples, colored by sample identity. B UMAP projection colored by unsupervised clustering results. C Annotation of nine major immune cell types based on canonical marker genes. D Proportion of each major immune cell type in HC and PD groups. E Dot plot showing the expression levels and detection rates of genetically prioritized eGenes across major immune cell types. F Representative UMAP feature plots illustrating cell-type-specific expression patterns of HLA-DQA1 and CTSB. G Proportion of significantly upregulated and downregulated genes per immune cell type. H Cell-type-specific differential expression of prioritized eGenes.

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