Fig. 7: Immune-related trait associations identified by SNP-level PheWAS in Open Targets Platform and FinnGen. | npj Parkinson's Disease

Fig. 7: Immune-related trait associations identified by SNP-level PheWAS in Open Targets Platform and FinnGen.

From: Peripheral immune cell-specific genes in Parkinson’s disease uncovered by multi-omics with therapeutic implications

Fig. 7: Immune-related trait associations identified by SNP-level PheWAS in Open Targets Platform and FinnGen.The alternative text for this image may have been generated using AI.

Sankey plots illustrating significant immune-related phenotypic associations for SNPs corresponding to prioritized eGenes. A Direct immune measurements, including lymphocyte count and measurement of C-reactive protein (CRP), cathepsin B (CTSB), leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4), and collectin-12 (CL-12). B Immune-related diseases, including anti-citrullinated protein antibody-positive rheumatoid arthritis (ACPA + RA), polyarthropathies, seropositive rheumatoid arthritis (SPRA), coeliac disease (CD), ankylosing spondylitis (AS), subacute thyroiditis (SAT), spondyloarthritis (SpA), thyroiditis, psoriasis vulgaris (PV), juvenile arthritis (JIA). Cell types represent the source of the eGene, with links to the corresponding SNP and associated traits. *measurement. #count.

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