Fig. 3: Effects of intrathecal injection of dopamine receptor agonists on motor asymmetry, mechanical allodynia and thermal hyperalgesia.
From: Targeting the hypothalamic a11 nucleus to treat parkinsonian-like nociceptive impairments
A, B Schematic representation of the 6-OHDA injection into the MFB (A) and the intrathecal injection of dopamine agonists/antagonists of D1 and D2 receptors (B). C–E Histograms showing the percentage of use of the left (C), right (D), and both paws (E) in the cylinder test. F, G Histograms showing the withdrawal threshold (in grams) of the left (F) and right (G) paws in the von Frey test. H, I Histograms showing the withdrawal latency (in seconds) of the left (H) and right (I) paws in the plantar test. Data obtained in sham (n = 12) and 6-OHDA (n = 12) rats and presented in the graphs as the means ± S.E.M. Mann–Whitney test was used to compare the values of sham versus 6-OHDA animals (*p < 0.05, **p < 0.01, ****p < 0.0001). Friedman test was used to compare the data of the different treatments, followed by the post hoc “Dunn’s multiple comparisons test” in 6-OHDA rats (#p < 0.05, ##p < 0.01, ###p < 0.001, ####p < 0.0001).
