Fig. 7: DCZ activation of hM3Dq receptors increased the number of A11 TH-positive neurons expressing pERK in the 6-OHDA rat model of hemiparkinsonism.
From: Targeting the hypothalamic a11 nucleus to treat parkinsonian-like nociceptive impairments
A–C Coronal sections of the A11 hypothalamic nucleus showing TH-positive neurons (left, red), pERK-positive neurons (middle, green) and the merge (right, orange) in the three groups of animals: 6-OHDA rats infected with hM3Dq receptors in the right A11 (A), 6-OHDA m-Cherry non infected animals (B) and sham mCherry rats (C). D, F Histograms showing the number of TH-positive neurons expressing pERK in the right A11 of the three groups of rats. Note that DCZ significantly increased the number of these neurons in the right transfected side with hM3Dq but not the left non-transfected side (E, F). Data are mean±S.E.M analyzed using Kruskal–Wallis test, ***p < 0.0001, ****p < 0.00001, ns: non-significant.
