Table 1 Independent signals in TMEM175, SCARB2 and CTSB

From: TMEM175, SCARB2 and CTSB associations with Parkinson’s disease risk across populations

TMEM175

Ancestry

variant

A1

A2

MAF

(cases)

MAF

(controls)

OR (95%CI)

P value

pJ

location

EUR

rs34311866 p. Met393Thr

C

T

0.21

0.18

1.25(1.19-1.32)

6.07e-16

6.65e-16

exon

AJ

rs6599388

T

C

0.45

0.54

0.60(0.48-0.74)

2.41e-06

2.88e-06

intron

EAS

rs3755956

T

C

0.094

0.11

0.71(0.60-0.84)

7.87e-05

8.14e-05

intron

SCARB2

EUR

rs11547135

T

C

0.36

0.33

1.11(1.06-1.16)

1.01e-05

1.01e-05

intron

AJ

rs530111925

T

C

0.011

0.022

0.24(0.13-0.47)

3.03e-05

3.22e-05

intron

AMR

rs73828719

G

C

0.083

0.063

0.63(0.50-0.78)

3.55e-05

3.71e-05

intron

CTSB

EUR

rs1293289

A

G

0.27

0.29

0.89(0.85-0.93)

1.13e-06

1.14e-06

intron

AMR

rs73551266

C

T

0.023

0.021

0.48(0.33-0.70)

1.52e-04

1.56e-04

intron

  1. Location of variants are based on GRCh38/hg38. Bonferroni correction was applied for multiple testing to define the significance threshold. The corrected p-value thresholds were 4.67e-04 for TMEM175, 3.55e-04 for SCARB2, and 4.31e-04 for CTSB.
  2. AJ Ashkenazi Jewish, AMR Latino and indigenous Americas, EAS East Asian, EUR European, A1 alternative allele, A2 reference allele, MAF minor allele frequency, OR odds ratio, P value, p-value from the original association analysis, pJ p-value from a joint analysis of all the selected variants.
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