Fig. 2: Longitudinal change in the aperiodic exponent and association with change in rigidity across the cortex and in the left postcentral region of interest as an example.
From: Magnetoencephalography-based prediction of longitudinal symptom progression in Parkinson’s disease
Left panel: Upper row: Group x time interaction across brain regions for the aperiodic exponent, only displaying t statistics for regions with a significant interaction effect defined by pFDR < 0.05. Middle rows: Main effects of time per group for illustration of the overall trends over time. Lowest row illustrating the results of the ANCOVA for the relationship between change in aperiodic exponent and rigidity progression. Asterix indicates regions with for which the ANCOVA model described in the main text resulted in a significant effect with an FDR-corrected p-value < 0.05. Coloring represents the respective t-values of this effect. Right panel: Upper row: Aperiodic component of the neuronal signal as derived from parametrization by group and time point in the left postcentral region. Lower row: Relationship between change in the aperiodic exponent and annual rigidity progression rate. R² in the upper right corner is the partial R² indicating how much of the variance in clinical change is explained by adding change in the aperiodic exponent to the ANCOVA model. The gray area represents the 95%-confidence interval around the fitted regression line in pink.
