Fig. 1: α-Syn PFFs induce mitochondrial fragmentation. | npj Parkinson's Disease

Fig. 1: α-Syn PFFs induce mitochondrial fragmentation.

From: Systematic evaluation of mitochondrial morphology regulators for amelioration of neuronal α-synucleinopathy

Fig. 1: α-Syn PFFs induce mitochondrial fragmentation.The alternative text for this image may have been generated using AI.

a, b Images of mitochondria in dendrites and axons. Both dendritic and axonal mitochondria showed reduced length in α-Syn PFFs-treated neurons. c) Images of p-α-Syn accumulation. d, e Quantification of dendritic and axonal mitochondrial length using MitoVis. nControl = 22 neurons, nα-Syn = 23 neurons. Samples were obtained from 4 independent experiments from different pups. Number of mitochondria is annotated at the bottom of bar graphs. Unpaired t-test, ****p < 0.0001, a, c Scale bar = 20 μm, b Scale bar = 5 μm.

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