Fig. 4: Protecting mitochondrial morphologies could preserve spine density at control level. | npj Parkinson's Disease

Fig. 4: Protecting mitochondrial morphologies could preserve spine density at control level.

From: Systematic evaluation of mitochondrial morphology regulators for amelioration of neuronal α-synucleinopathy

Fig. 4: Protecting mitochondrial morphologies could preserve spine density at control level.The alternative text for this image may have been generated using AI.

a Secondary dendritic segments of primary cortical neurons. Spine density was reduced in α-Syn PFFs-treated neurons. b Quantification of dendritic spine density. Mfn1/2 overexpression maintained spine density. One-way ANOVA, ***p = 0.0004, #p = 0.0235 (for Mfn1), #p = 0.0139 (for Mfn2). c Quantification of dendritic spine density. Knockdown of Mff and Fis1 maintained spine density. nControl_Fusion = 34 neurons, nα-Syn_Fusion = 33 neurons, nα-Syn+Mfn1 = 15 neurons, nα-Syn+Mfn2 = 15 neurons, nControl_Fission = 16 neurons, nα-Syn_Fission = 17 neurons, nα-Syn+shMff = 18 neurons, nα-Syn+shFis1 = 18 neurons. 2 dendrites/neuron. Samples were obtained from 5 independent experiments for Mfn/2 and 3 independent experiments for shMff/shFis1 from different pups. One-way ANOVA, ***p = 0.0005, ####p < 0.0001, n.s. not significant. Scale bar = 5 μm.

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