Table 2 Significant differences in adjusted hazard ratios of selected split variables between sibling or comparison nodes.

Node 26

Ever smoker aged >64 years in the absence of COPD with metformin use

1

Node 27

Ever smoker aged >64 years in the presence of COPD with metformin use

2.09 (1.55–2.82)

Node {5,6,8,9}

Never smoker aged ≤64 years

1

Node {13,14,15,16}

Ever smoker aged ≤64 years

3.24 (2.77–3.80)

Node {19,20}

Never smoker aged >64 years

1

Node {23,24,26,27}

Ever smoker aged >64 years

3.12 (2.81–3.46)

Node {5,6,8,9}

Young Never Smoker

1

1

Node {13,14,15,16}

Young Ever Smoker

2.83 (2.48–3.24)

2.83 (2.48–3.24)

Node {19,20}

Old Never Smoker

1.30 (1.12–1.50)

1.30 (1.12–1.50)

Node {23,24}

Old Ever Smoker with short diabetes history

4.10 (3.48–4.83)

4.10 (3.48–4.83)

Node 26

Old Ever Smoker with long diabetes history and absence of COPD

4.10 (3.50–4.81)

4.11 (3.50–4.81)

Node 27

Old Ever Smoker with long diabetes history and presence of COPD

8.33 (6.04–11.50)

8.38 (6.07–11.57)