Table 4 Subgroup Analyses.

From: Development and validation of a machine learning risk prediction model for asthma attacks in adults in primary care

Characteristic

Characteristic Value

Characteristic Prevalence (%)

Attack Rate in Samples

Sensitivity

Specificity

PPV

NPV

History of comorbid Chronic Pulmonary Disease

Yes

0.8

39.3

85.9

67.6

28.1

97.0

No

99.2

7.1

29.4

95.1

36.6

93.3

Future COPD Diagnosis

None Recorded*

95.9

6.9

30.4

95.2

36.4

93.8

Within 5 Years

2.0

14.3

36.6

90.1

42.2

87.8

In more than 5 Years Time

2.1

21.6

22.8

78.8

29.2

72.7

More than one respiratory infection in previous calendar year or current calendar year to date

Yes

2.6

57.6

80.8

52.2

41.5

86.6

No

97.4

60

25.2

95.7

34.8

93.4

BTS/SIGN Treatment Step

0

6.8

2.9

21.3

98.6

56.5

93.7

1

21.7

1.3

8.2

99.0

28.3

95.9

2

9.7

3.3

10.7

97.1

16.7

95.2

3

27.6

5.2

16.9

95.8

25.1

93.3

4

34.2

15

43.3

89.6

40.2

90.7

More than one asthma related consultation in previous calendar year, or current calendar year to date

Yes

13.1

29.8

60.9

78.3

42.1

88.5

No

86.9

4.0

16.7

97.0

29.6

93.8

More than one OCS prescription in previous calendar year, or current calendar year to date

Yes

2.3

96.8

100

6.1

49.0

100

No

97.7

5.2

20.1

96.1

30.6

93.3

Asthma attack recorded in primary care in the last 2 years

Yes

14.3

46.3

70.3

61.4

37.0

86.5

No

85.7

0.8

3.8

99.4

28.7

93.9

Peak Flow Measurement in the last week

Yes

2.4

9.8

40.4

93.0

35.3

94.3

No

97.6

7.3

29.8

94.9

36.2

93.3

Blood Eosinophil Measurement ever recorded

Yes

27.3

11.9

38.3

91.3

34.4

92.5

No

72.7

5.7

26.1

96.2

37.7

93.6

Smoking Status

Current

14.9

12.9

29.9

89.5

28.2

90.3

Former

16.7

12.1

42.8

91.7

39.0

92.8

Never

68.4

5.0

25.7

96.7

39.1

94.0

  1. *Those with no future COPD diagnosis recorded will have at least one year of follow-up after the observation date, but no further stratification by follow-up was conducted.