Fig. 7: Histological evaluation of re-epithelialization and collagen remodeling. | npj Regenerative Medicine

Fig. 7: Histological evaluation of re-epithelialization and collagen remodeling.

From: Novel copper-ion coordinated andrographolide-loaded hydrogel activates Rac1/JNK1 axis for enhancing diabetic wound healing

Fig. 7: Histological evaluation of re-epithelialization and collagen remodeling.

A–C Representative graphs and statistics of H&E and Masson’s trichrome staining of wound tissues at days 3 and 7 post-injury for each treatment group, with corresponding quantitative analyses (n = 6). H&E images highlight epidermal thickness, granulation tissue formation, and inflammatory cell infiltration. Note: Blue arrows represent hair follicles, red arrows represent sebaceous glands, black arrows represent lymphatic vessels, and green arrows represent collagen fibers. Masson’s trichrome staining specifically highlights collagen fibers in blue. Scale Bar: 50 μm. D–F Immunohistochemical analysis and quantification of collagen deposition. Representative images (D) and statistical data show the expression of Col I (E) and Col III (F) in wound tissues at days 3 and 7 post-wounding (n = 3). Brown deposits indicate positive immunoreactivity for the respective collagen types. Scale bar: 50 μm. The bar charts present mean ± SD. *P < 0.05, ***P < 0.001, vs Control group, #P < 0.05, ##P < 0.01, ###P < 0.001, vs Matrix group.

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