Fig. 1: Cardiomyocytes from patients suffering laminopathies exhibit shortened telomeres.

A Paraffin-embedded cardiac samples of laminopathy patients (N = 13 patients; n = 130–540 nuclei per patient tissue), control patients (healthy: N = 6 patients; n = 91-186 nuclei per patient tissue, and transplanted hearts: N = 12; n = 133–887 nuclei per patient tissue) were used for myocardial telomere Q-FISH quantification. Telomere intensities (a.u.) were scored in a blinded fashion within five to six regions of interest in two nonconsecutive sections. Created in BioRender. Wang, C. (2025) https://BioRender.com/8hmmn43. B Telomere levels per patient is or (C) per genotype are plotted. Data represent mean ± SEM. Student’s t-test for (B) and one-way ANOVA tests for (C) were used to calculate significance. D Average telomere levels and age of laminopathy patients and healthy controls are plotted and best-fit linear curves are shown. Extremely low telomere LGMD1B sample (blue triangle) was considered an outlier and was not included for determining best-fit linear curve.