Fig. 3: LMNA+/mut hiPSC-CMs exhibit altered force generation measured by traction force microscopy.
From: Telomere shortening in laminopathic dilated cardiomyopathy
Contractile assessment of LMNA+/mut and isogenic control LMNA+/+ hiPSC-CMs using traction force microscopy was performed on 10 kPa or 35 kPa hydrogels. (A) Force, (B) Displacement, (C) Contraction velocity, (D) Strain, (E) Area, and (F) beat rate of single LMNA+/+ and LMNA+/mut hiPSC-CMs subjected to 10 kPa and 35 kPa hydrogels under 1 Hz electrical pacing were measured (n = 3 independent experiments, 17–23 cells were analyzed). Data represent mean ± SEM. Student’s t-tests were used to calculate significance.
