Table 5 a) Whole hippocampus volume pairwise between-group baseline comparison analysis of FEP-NR, FEP-R, CHR-NR, CHR-R and CTR, including age, sex, total intracranial volume and body mass index as covariates. b) Subregional post-hoc pairwise between-group baseline comparison analysis of FEP-NR, FEP-R, CHR-NR, CHR-R and CTR, including age, sex, total intracranial volume and BMI as covariates.

From: Longitudinal study on hippocampal subfields and glucose metabolism in early psychosis

a) Volume	Contrast baseline	Estimated difference (mm³)	95 % Confidence Interval	DF	t-ratio	p	FDR corrected p	p with exposure*	FDR corrected p with exposure*
Whole hippocampus	CTR - CHR-NR	250	54.250–445.36	121	2.529	0.0127	0.0424	0.0243	0.0932
Whole hippocampus	CTR - CHR-R	28	−146.636–203.56	121	0.322	0.7482	0.8979	0.7569	0.8410
Whole hippocampus	CTR - FEP-NR	223	67.950–378.72	121	2.846	0.0052	0.0260	0.0278	0.0932
Whole hippocampus	CTR - FEP-R	215	67.189–363.37	121	2.878	0.0047	0.0260	0.0280	0.0932
Whole hippocampus	CHR-NR - CHR-R	−221	−451.942–9.25	121	−1.900	0.0598	0.1049	0.0892	0.2229
Whole hippocampus	CHR-NR - FEP-NR	−26	−241.754–188.81	121	−0.243	0.8081	0.8979	0.7089	0.8410
Whole hippocampus	CHR-NR - FEP-R	−35	−248.390–179.34	121	−0.320	0.7498	0.8979	0.6538	0.8410
Whole hippocampus	CHR-R - FEP-NR	195	−0.993–390.75	121	1.970	0.0512	0.1049	0.1228	0.2403
Whole hippocampus	CHR-R - FEP-R	187	−10.222–383.86	121	1.877	0.0629	0.1049	0.1442	0.2403
Whole hippocampus	FEP-NR - FEP-R	−8	−186.384–170.27	121	−0.089	0.9289	0.9289	0.9300	0.9300

b) Volume	Contrast baseline	Estimated difference (mm³)	95 % Confidence Interval	DF	t-ratio	p	FDR corrected p	p with exposure*	FDR corrected p with exposure*
Tail	CTR - CHR-NR	67.379	35.855–98.903	121	4.231	<0.0001	0.00182	0.0001	0.0072
Tail	CTR - CHR-R	19.973	−8.210–48.155	121	1.403	0.1632	0.38391	0.1656	0.5282
Tail	CTR - FEP-NR	43.389	18.690–68.089	121	3.478	0.0007	0.01875	0.0029	0.0771
Tail	CTR - FEP-R	51.407	27.511–75.303	121	4.259	<0.0001	0.00182	0.0003	0.0101
Tail	CHR-NR - CHR-R	−47.406	−84.796 to −10.017	121	−2.510	0.0134	0.15301	0.0187	0.3298
Tail	CHR-NR - FEP-NR	−23.989	−58.765–10.786	121	−1.366	0.1746	0.38792	0.1503	0.5282
Tail	CHR-NR - FEP-R	−15.972	−50.516–18.573	121	−0.915	0.3618	0.68920	0.3198	0.6560
Tail	CHR-R - FEP-NR	23.417	−8.270–55.104	121	1.463	0.1460	0.37689	0.2307	0.5558
Tail	CHR-R - FEP-R	31.434	−0.243–63.112	121	1.965	0.0518	0.27602	0.0927	0.4946
Tail	FEP-NR - FEP-R	8.018	−20.477–36.512	121	0.557	0.5785	0.82737	0.5779	0.8746
Presubiculum	CTR - CHR-NR	19.637	−11.887–51.162	121	1.233	0.2199	0.46288	0.2805	0.6066
Presubiculum	CTR - CHR-R	−6.195	−34.377–21.987	121	−0.435	0.6642	0.88558	0.6585	0.8746
Presubiculum	CTR - FEP-NR	20.706	−3.994–45.406	121	1.660	0.0996	0.31864	0.1958	0.5353
Presubiculum	CTR - FEP-R	25.921	2.025–49.817	121	2.148	0.0337	0.25340	0.0818	0.4946
Presubiculum	CHR-NR - CHR-R	−25.833	−63.222–11.557	121	−1.368	0.1739	0.38792	0.2141	0.5353
Presubiculum	CHR-NR - FEP-NR	1.069	−33.707–35.844	121	0.061	0.9516	0.97025	0.9787	0.9884
Presubiculum	CHR-NR - FEP-R	6.284	−28.261–40.828	121	0.360	0.7194	0.92645	0.7864	0.9399
Presubiculum	CHR-R - FEP-NR	26.901	−4.786–58.588	121	1.681	0.0954	0.31864	0.1591	0.5282
Presubiculum	CHR-R - FEP-R	32.116	0.439–63.794	121	2.007	0.0470	0.27484	0.0851	0.4946
Presubiculum	FEP-NR - FEP-R	5.215	−23.280–33.710	121	0.362	0.7177	0.92645	0.7170	0.9105
Subiculum	CTR - CHR-NR	9.147	−22.377–40.672	121	0.574	0.5667	0.82737	0.6669	0.8746
Subiculum	CTR - CHR-R	−1.670	−29.853–26.512	121	−0.117	0.9068	0.96723	0.9006	0.9510
Subiculum	CTR - FEP-NR	18.578	−6.122–43.278	121	1.489	0.1391	0.37086	0.2575	0.5723
Subiculum	CTR - FEP-R	21.118	−2.778–45.014	121	1.750	0.0827	0.31864	0.1717	0.5282
Subiculum	CHR-NR - CHR-R	−10.818	−48.207–26.572	121	−0.573	0.5678	0.82737	0.6472	0.8746
Subiculum	CHR-NR - FEP-NR	9.430	−25.345–44.206	121	0.537	0.5923	0.82737	0.6554	0.8746
Subiculum	CHR-NR - FEP-R	11.971	−22.574–46.515	121	0.686	0.4940	0.79039	0.5521	0.8746
Subiculum	CHR-R - FEP-NR	20.248	−11.439–51.935	121	1.265	0.2083	0.45032	0.3137	0.6560
Subiculum	CHR-R - FEP-R	22.789	−8.889–54.466	121	1.424	0.1570	0.38049	0.2452	0.5604
Subiculum	FEP-NR - FEP-R	2.540	−25.954–31.035	121	0.177	0.8602	0.96723	0.8594	0.9469
CA1	CTR - CHR-NR	38.794	7.270–70.318	121	2.436	0.0163	0.16294	0.0246	0.3298
CA1	CTR - CHR-R	0.749	−27.433–28.931	121	0.053	0.9581	0.97025	0.9644	0.9884
CA1	CTR - FEP-NR	32.708	8.008–57.408	121	2.622	0.0099	0.15301	0.0282	0.3298
CA1	CTR - FEP-R	28.220	4.324–52.116	121	2.338	0.0210	0.18692	0.0551	0.4408
CA1	CHR-NR - CHR-R	−38.045	−75.435 – −0.656	121	−2.014	0.0462	0.27484	0.0610	0.4433
CA1	CHR-NR - FEP-NR	−6.086	−40.862–28.689	121	−0.346	0.7296	0.92645	0.6661	0.8746
CA1	CHR-NR - FEP-R	−10.574	−45.118–23.971	121	−0.606	0.5457	0.82737	0.4910	0.8539
CA1	CHR-R - FEP-NR	31.959	0.272–63.646	121	1.997	0.0481	0.27484	0.0871	0.4946
CA1	CHR-R - FEP-R	27.471	−4.206–59.149	121	1.717	0.0886	0.31864	0.1488	0.5282
CA1	FEP-NR - FEP-R	−4.488	−32.982–24.007	121	−0.312	0.7557	0.94467	0.7565	0.9311
Molecular layer	CTR - CHR-NR	33.984	2.460–65.508	121	2.134	0.0348	0.25340	0.0504	0.4408
Molecular layer	CTR - CHR-R	2.531	−25.651–30.713	121	0.178	0.8592	0.96723	0.8653	0.9469
Molecular layer	CTR - FEP-NR	32.580	7.881–57.280	121	2.611	0.0102	0.15301	0.0289	0.3298
Molecular layer	CTR - FEP-R	30.816	6.920–54.712	121	2.553	0.0119	0.15301	0.0342	0.3419
Molecular layer	CHR-NR - CHR-R	−31.453	−68.842–5.937	121	−1.665	0.0984	0.31864	0.1251	0.5282
Molecular layer	CHR-NR - FEP-NR	−1.403	−36.179–33.372	121	−0.080	0.9365	0.97025	0.8677	0.9469
Molecular layer	CHR-NR - FEP-R	−3.168	−37.712–31.377	121	−0.182	0.8563	0.96723	0.7892	0.9399
Molecular layer	CHR-R - FEP-NR	30.050	−1.638–61.737	121	1.877	0.0629	0.31432	0.1103	0.5282
Molecular layer	CHR-R - FEP-R	28.285	−3.392–59.962	121	1.768	0.0796	0.31864	0.1355	0.5282
Molecular layer	FEP-NR - FEP-R	−1.764	−30.259–26.730	121	−0.123	0.9026	0.96723	0.9034	0.9510
GCMLDG	CTR - CHR-NR	22.724	−8.800–54.249	121	1.427	0.1561	0.38049	0.2044	0.5353
GCMLDG	CTR - CHR-R	7.342	−20.841–35.524	121	0.516	0.6070	0.82737	0.6125	0.8746
GCMLDG	CTR - FEP-NR	22.494	−2.206–47.193	121	1.803	0.0739	0.31864	0.1530	0.5282
GCMLDG	CTR - FEP-R	20.227	−3.669–44.123	121	1.676	0.0964	0.31864	0.1945	0.5353
GCMLDG	CHR-NR - CHR-R	−15.383	−52.772–22.007	121	−0.815	0.4170	0.73431	0.4859	0.8539
GCMLDG	CHR-NR - FEP-NR	−0.231	−35.006–34.545	121	−0.013	0.9895	0.98954	0.9201	0.9560
GCMLDG	CHR-NR - FEP-R	−2.498	−37.042–32.047	121	−0.143	0.8864	0.96723	0.8187	0.9469
GCMLDG	CHR-R - FEP-NR	15.152	−16.535–46.839	121	0.947	0.3457	0.67453	0.4845	0.8539
GCMLDG	CHR-R - FEP-R	12.885	−18.792–44.562	121	0.805	0.4222	0.73431	0.5736	0.8746
GCMLDG	FEP-NR - FEP-R	−2.267	−30.762–26.228	121	−0.157	0.8751	0.96723	0.8759	0.9469
CA2/3	CTR - CHR-NR	24.605	−6.919–56.129	121	1.545	0.1249	0.35685	0.1662	0.5282
CA2/3	CTR - CHR-R	7.670	−20.512–35.852	121	0.539	0.5910	0.82737	0.5964	0.8746
CA2/3	CTR - FEP-NR	20.066	−4.634–44.766	121	1.608	0.1104	0.33957	0.2130	0.5353
CA2/3	CTR - FEP-R	11.533	−12.363–35.429	121	0.956	0.3412	0.67453	0.5385	0.8746
CA2/3	CHR-NR - CHR-R	−16.935	−54.325–20.454	121	−0.897	0.3717	0.69144	0.4365	0.8516
CA2/3	CHR-NR - FEP-NR	−4.539	−39.314–30.236	121	−0.258	0.7965	0.95249	0.7309	0.9136
CA2/3	CHR-NR - FEP-R	−13.072	−47.617–21.473	121	−0.749	0.4552	0.75869	0.4063	0.8125
CA2/3	CHR-R - FEP-NR	12.396	−19.291–44.083	121	0.775	0.4401	0.74918	0.5947	0.8746
CA2/3	CHR-R - FEP-R	3.863	−27.814–35.541	121	0.241	0.8096	0.95249	0.9884	0.9884
CA2/3	FEP-NR - FEP-R	−8.533	−37.028–19.962	121	−0.593	0.5544	0.82737	0.5551	0.8746
CA4	CTR - CHR-NR	23.870	−7.654–55.394	121	1.499	0.1365	0.37086	0.1804	0.5346
CA4	CTR - CHR-R	7.276	−20.906–35.458	121	0.511	0.6102	0.82737	0.6157	0.8746
CA4	CTR - FEP-NR	22.474	−2.226–47.174	121	1.801	0.0741	0.31864	0.1534	0.5282
CA4	CTR - FEP-R	18.784	−5.112–42.681	121	1.556	0.1223	0.35685	0.2362	0.5558
CA4	CHR-NR - CHR-R	−16.594	−53.983–20.796	121	−0.879	0.3813	0.69334	0.4471	0.8516
CA4	CHR-NR - FEP-NR	−1.396	−36.171–33.380	121	−0.079	0.9368	0.97025	0.8680	0.9469
CA4	CHR-NR - FEP-R	−5.086	−39.630–29.459	121	−0.291	0.7712	0.94917	0.7065	0.9105
CA4	CHR-R - FEP-NR	15.198	−16.489–46.885	121	0.950	0.3442	0.67453	0.4828	0.8539
CA4	CHR-R - FEP-R	11.508	−20.169–43.186	121	0.719	0.4734	0.77286	0.6318	0.8746
CA4	FEP-NR - FEP-R	−3.690	−32.184–24.805	121	−0.256	0.7981	0.95249	0.7989	0.9399

CA cornu ammonis, Molecular Layer Molecular Layer of the CA fields and subiculum, GCMLDG The Granule Cell and Molecular Layer of the Dentate Gyrus, FDR false discovery rate.
FEP first-episode psychosis, CHR-R clinical high-risk patient in remission, CHR-N CHR not in remission, FEP-R first-episode psychosis patient in remission, FEP-NR FEP not in remission at the follow-up, CTR population controls.
*Total lifetime antipsychotic exposure included in the model.
Sample sizes:
FEP nonremission, FEP-NR: baseline n = 24, follow-up n = 12.
FEP remission, FEP-R: baseline n = 25, follow-up n = 22.
CHR nonremission, CHR-NR: baseline n = 12, follow-up n = 7.
CHR remission, CHR-R: baseline n = 16, follow-up n = 15.
CTR: baseline n = 53, follow-up n = 48.
*Total lifetime antipsychotic exposure included in the model.

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