Table 3 Associations between system-specific metrics and comorbidity clusters.

From: Comorbidity patterns and immune-metabolic differences in patients with acute-episode of schizophrenia spectrum disorders

Metrics	SSD only	High-risk metabolic multisystem disorders cluster		Low-risk metabolic multisystem disorders cluster		Sleep disorders cluster
Metrics	SSD only	β	P value	β	P value	β	P value
Lipid metabolism metrics
Low Density Lipoprotein Cholesterol, mmol/L	Ref	0.260	0.064	0.113	0.009*†	0.046	0.463
Total cholesterol, mmol/L	Ref	−0.045	0.794	0.007	0.901	−0.009	0.904
Free Fatty Acids, mmol/L	Ref	−0.033	0.574	0.005	0.829	−0.055	0.178
Triglyceride, mmol/L	Ref	−0.136	0.493	0.008	0.892	−0.101	0.258
Apolipoprotein AI, g/L	Ref	−0.173	0.002*†	−0.028	0.241	0.050	0.197
Apolipoprotein B, g/L	Ref	0.181	<0.001*†	0.032	0.112	−0.071	0.032*
Apolipoprotein A, mg/L	Ref	90.620	<0.001*†	35.407	<0.001*†	2.021	0.862
High-density lipoprotein cholesterol, mmol/L	Ref	−0.022	0.692	0.002	0.904	0.025	0.301
Systemic inflammation metrics
Platelet-larger cell ratio, %	Ref	1.943	0.338	0.347	0.758	−3.160	0.589
Mean platelet volume, fl	Ref	0.994	0.002*†	0.267	0.008*†	−0.271	0.074
Mean corpuscular hemoglobin concentration, g/L	Ref	2.300	0.170	0.731	0.176	1.321	0.103
Mean Corpuscular Hemoglobin, pg	Ref	−0.338	0.367	0.067	0.578	0.021	0.907
Red blood cell, 10^12/L	Ref	0.143	0.076	0.048	0.065	0.080	0.041*
Red Cell Distribution Width Coefficient of Variation, %	Ref	1.182	<0.001*†	0.294	<0.001*†	−0.221	0.021*
Red Cell Distribution Width - Standard Deviation, fl	Ref	−0.684	0.388	0.262	0.550	−0.726	0.751
Mean corpuscular volume, fl	Ref	−1.661	0.078	0.032	0.917	−0.307	0.500
Hematocrit, %	Ref	−35.131	<0.001*†	−9.807	<0.001*†	0.638	0.473
Platelet, 10^9/L	Ref	9.709	0.360	5.305	0.120	3.631	0.478
Platelet distribution width, fl	Ref	−3.966	<0.001*†	−1.344	<0.001*†	0.389	0.039*
Plateletcrit, %	Ref	0.035	<0.001*†	0.012	<0.001*†	−0.005	0.273
Hemoglobin, g/L	Ref	2.406	0.320	1.625	0.037*	2.139	0.068
Aggregate index of systemic inflammation	Ref	−37.951	0.532	40.439	0.038*	81.065	0.006*†
Monocyte to high-density lipoprotein cholesterol ratio	Ref	0.057	0.250	−0.024	0.186	0.002	0.931
Monocyte-to-lymphocyte ratio	Ref	−0.037	0.159	−0.006	0.461	0.024	0.058
Neutrophil-to-lymphocyte ratio	Ref	−0.673	0.091	−0.091	0.476	0.465	0.016*†
Platelet-to-lymphocyte ratio	Ref	−15.619	0.222	−11.294	0.006*†	5.066	0.413
Systemic immune-inflammation index	Ref	−113.431	0.265	−4.660	0.887	116.037	0.018*
System inflammation response index	Ref	−0.244	0.309	0.123	0.110	0.346	0.003*†
C-reactive protein, mg/L	Ref	−0.225	0.936	0.311	0.699	−0.180	0.860
Derived neutrophil to lymphocyte ratio	Ref	−0.473	0.063	−0.102	0.212	0.101	0.411
Neutrophil percentage, %	Ref	−4.315	0.012*†	−1.009	0.067	2.721	0.001*†
Absolute neutrophil count, 10^9/L	Ref	−0.163	0.603	0.272	0.007*†	0.606	<0.001*†
Monocytes percentage, %	Ref	0.019	0.955	−0.040	0.707	−0.119	0.455
Absolute monocyte count, 10^9/l	Ref	0.031	0.276	0.025	0.006*†	0.031	0.024*
Basophil percentage, %	Ref	0.294	<0.001*†	0.068	<0.001*†	−0.027	0.149
Absolute basophil count, 10^9/L	Ref	0.030	<0.001*†	0.009	<0.001*†	−0.004	0.019*
Eosinophil percentage, %	Ref	0.983	<0.001*†	0.182	0.009*†	−0.298	0.005*†
Absolute eosinophil count, 10^9/L	Ref	0.075	<0.001*†	0.015	0.004*†	−0.018	0.021*
Antistreptolysin O, IU/ml	Ref	276.795	<0.001*†	12.763	0.072	4.975	0.572
Lymphocyte percentage, %	Ref	3.019	0.050*	0.798	0.107	−2.277	0.002*†
Absolute lymphocytes count, 10^9/L	Ref	0.306	0.004*†	0.155	<0.001*†	−0.035	0.487
white blood cell, 10^9/L	Ref	0.277	0.421	0.476	<0.001*†	0.568	<0.001*†
Rheumatoid factor, IU/ml	Ref	−8.188	0.385	−0.625	0.471	−2.275	0.035*
Serum amyloid A, mg/L	Ref	−4.500	0.667	−4.065	0.197	−5.422	0.178

Adjusted for age, gender, Admission Count; The neutrophil percentage was analyzed using a linear regression model, while all other variables were analyzed using generalized linear models.
*P value <0.05; †FDR value <0.05.

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Table 3 Associations between system-specific metrics and comorbidity clusters.

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