Table 3 Meta-regressions statistics of dopamine subsystem dysfunction in schizophrenia by different PET markers.
From: Resolving the heterogeneity of dopamine subsystems dysfunction in schizophrenia: a PET meta-analysis
Marker | Region | Stats type | Effect β | 95%CI | z | p |
|---|---|---|---|---|---|---|
D2/3 | ||||||
STR | Age Effect | −0.01 | [−0.05, 0.03] | −0.59 | 0.554 | |
STR | Year Effect | −0.05 | [−0.09, −0.02] | −2.83 | 0.005 | |
STR | Sex Effect | 4.06 | [1.20, 6.92] | 2.78 | 0.005 | |
STR | Duration Effect | −0.01 | [−0.07, 0.04] | −0.50 | 0.615 | |
STR | Severity Effect | 0.02 | [−0.002, 0.05] | 1.80 | 0.071 | |
THA | Age Effect | −0.09 | [−0.20, 0.01] | −1.81 | 0.071 | |
THA | Year Effect | 0.02 | [−0.04, 0.07] | 0.51 | 0.607 | |
THA | Sex Effect | −0.45 | [−2.42, 1.51] | −0.45 | 0.652 | |
THA | Duration Effect | −0.01 | [−0.11, 0.08] | −0.31 | 0.754 | |
THA | Severity Effect | 0.01 | [−0.01, 0.02] | 0.83 | 0.406 | |
LIB | Age Effect | −0.07 | [−0.27, 0.12] | −0.72 | 0.470 | |
LIB | Year Effect | −0.02 | [−0.13, 0.10] | −0.3 | 0.764 | |
LIB | Sex Effect | −0.94 | [−3.92, 2.04] | −0.62 | 0.536 | |
LIB | Duration Effect | 0.03 | [−0.19, 0.25] | 0.26 | 0.794 | |
LIB | Severity Effect | 0.03 | [−0.04, 0.90] | 0.83 | 0.407 | |
SN | Age Effect | −0.16 | [−0.39, 0.07] | −1.37 | 0.171 | |
SN | Year Effect | −0.02 | [−0.27, 0.23] | −0.17 | 0.867 | |
SN | Sex Effect | 0.47 | [−8.45, 9.39] | 0.10 | 0.918 | |
SN | Severity Effect | 0.001 | [−0.12, 0.12] | −0.02 | 0.984 | |
TMC | Age Effect | −0.10 | [−0.23, 0.04] | −1.43 | 0.152 | |
TMC | Year Effect | 0.02 | [−0.06, 0.10] | 0.55 | 0.582 | |
TMC | Sex Effect | −0.40 | [−3.02, 2.22] | −0.30 | 0.765 | |
TMC | Duration Effect | −0.002 | [−0.12, 0.12] | −0.02 | 0.975 | |
TMC | Severity Effect | 0.03 | [−0.01, 0.06] | 1.53 | 0.126 | |
DSC | ||||||
STR | Age Effect | −0.02 | [−0.07, 0.03] | −0.85 | 0.397 | |
STR | Year Effect | −0.02 | [−0.06, 0.01] | −1.21 | 0.227 | |
STR | Sex Effect | 0.28 | [−1.38, 1.93] | 0.33 | 0.744 | |
STR | Duration Effect | −0.04 | [−0.13, 0.05] | −0.95 | 0.344 | |
STR | Severity Effect | 0.01 | [−0.01, 0.03] | 1.12 | 0.309 | |
LIB | Age Effect | −0.09 | [−0.22, 0.03] | −1.52 | 0.129 | |
LIB | Year Effect | −0.04 | [−0.13, 0.04] | −0.96 | 0.336 | |
LIB | Sex Effect | −1.14 | [−3.66, 1.38] | −0.89 | 0.374 | |
LIB | Duration Effect | 0.002 | [−0.06, 0.06] | −0.07 | 0.945 | |
D1 | ||||||
LIB | Age Effect | −0.06 | [−0.15, 0.03] | 1.33 | 0.183 | |
LIB | Year Effect | 0.003 | [−0.08, 0.09] | 0.08 | 0.936 | |
LIB | Duration Effect | −0.08 | [−0.23, 0.07] | −1.03 | 0.303 | |
LIB | Severity Effect | −0.07 | [−0.14, 0.01] | −1.71 | 0.088 | |
PFC | Age Effect | −0.12 | [0.22, −0.01] | −2.23 | 0.026 | |
PFC | Year Effect | 0.02 | [−0.10, 0.13] | 0.29 | 0.770 | |
PFC | Duration Effect | −0.16 | [−0.38, 0.07] | −1.35 | 0.177 | |
STR | Age Effect | −0.1 | [−0.16, −0.03] | −3.06 | 0.002 | |
STR | Year Effect | −0.004 | [−0.08, 0.07] | −0.1 | 0.921 | |
STR | Duration Effect | −0.16 | [−0.25, −0.08] | −3.74 | 0.0002 | |
STR | Severity Effect | −0.06 | [−3.36, −1.09] | −4.20 | 0.00003 | |
TMC | Age Effect | −0.11 | [−0.23, 0.01] | −1.84 | 0.065 | |
TMC | Year Effect | −0.04 | [−0.16, 0.09] | −0.61 | 0.545 | |
TMC | Duration Effect | −0.18 | [−0.37, 0.02] | −1.74 | 0.08 | |
TMC | Severity Effect | −0.13 | [−0.25, −0.01] | −2.05 | 0.040 | |
