Table 2 Odds ratios of miRNAs differentially expressed in patients with recent-onset schizophrenia and performance as diagnostic biomarkers.

	Variable	AUC (95% CI)	Odds ratio (95% CI)	p value	Adjusted p value
Upregulation	hsa-miR-511-5p	0.857 (0.717–0.997)	1.67 (1.21–3.26)	0.0356	0.0668
	hsa-miR-483-5p	0.686 (0.483–0.889)	1.22 (1.03–1.57)	0.0464	0.0773
	hsa-miR-200a-3p	0.657 (0.454–0.861)	1.16 (0.979–1.41)	0.109	0.1635
	hsa-miR-192-5p	0.543 (0.316–0.77)	1.95 (0.695–6.80)	0.235	0.3205
	hsa-miR-375-3p	0.500 (0.270–0.730)	1.15 (0.922–1.60)	0.277	0.3463
	hsa-miR-342-5p	0.529 (0.309–0.748)	1.03 (0.656–1.65)	0.882	0.882
	hsa-miR-342-3p	0.576 (0.358–0.794)	1.05 (0.895–1.25)	0.562	0.6485
	hsa-miR-99a-5p	0.633 (0.411–0.855)	0.923 (0.326–2.48)	0.865	0.9277
Downregulation	hsa-miR-143-3p	0.933 (0.803–1.00)	0.222 (0.0645–0.475)	0.00179	0.0269
	hsa-miR-423-3p	0.900 (0.757–1.00)	0.470 (0.251–0.732)	0.00454	0.0341
	hsa-miR-584-5p	0.848 (0.690–1.00)	0.440 (0.218–0.725)	0.00601	0.0301
	hsa-miR-361-5p	0.871 (0.730–1.00)	0.769 (0.606–0.916)	0.00915	0.0343
	hsa-miR-3184-5p	0.852 (0.712–0.993)	0.761 (0.577–0.913)	0.0136	0.0408
	hsa-miR-100-5p	0.810 (0.647–0.972)	0.370 (0.130–0.759)	0.025	0.0625
	hsa-miR-184	0.776 (0.605–0.948)	0.635 (0.383–0.891)	0.0308	0.066

The performance evaluation of each of the 15 differentially expressed miRNAs in patients with recent-onset schizophrenia as diagnostic biomarkers. The column of differential expression shows the expression changes in the recent-onset schizophrenia group of each microRNA compared to the control groups for the recent-onset schizophrenia. AUCs with 95% confidence intervals indicate miRNAs’ performances as biomarkers. Odds ratios with 95% confidence intervals, p values and adjusted p values from univariate logistic regression models are shown.
AUC area under the curve, 95% CI 95% confidence interval.

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