Fig. 6: Mediating effects of brain functional alterations on inflammation and cognitive function. | Schizophrenia

Fig. 6: Mediating effects of brain functional alterations on inflammation and cognitive function.

From: Peripheral inflammation mediates cognitive deficits in drug-naive schizophrenia through hippocampal-thalamo-visual circuitry dysfunction

Fig. 6: Mediating effects of brain functional alterations on inflammation and cognitive function.

A Spatial visualization of connectivity mappings associated with inflammatory markers and cognitive domains using BrainNet Viewer. B–D The mediation effect diagram in which the decreased FC of the THA-sLOC and HIPSubc-aPaHC couplings mediated inflammation and cognition (cytokines→brain FC→cognitive function). THA thalamus, sLOC lateral occipital cortex, superior division, HIPSubc the subiculum of the hippocampus, aPaHC parahippocampal gyrus, anterior division. WMS Wechsler Memory Scale. *P < 0.05, **P < 0.01, ***P < 0.001.

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