Fig. 1: T-2 toxin induces liver structural and functional damage. | npj Science of Food

Fig. 1: T-2 toxin induces liver structural and functional damage.

From: Lycopene mitigates T-2 toxin-induced hepatic ferroptosis by targeting the Nrf2/mitophagy axis in mice

Fig. 1: T-2 toxin induces liver structural and functional damage.The alternative text for this image may have been generated using AI.

A A schema diagram of C57 mice liver injury model. B Quantification of weight, liver coefficient, AST activity, ALT activity and Ishak score. C Representative images of liver autopsy photos and HE staining (Scale bar = 50 µm). Red triangle: inflammatory cell infiltration, Yellowe triangle: nuclear condensation, Blue triangle: cellular vacuolization. D–I The proteomic analysis of different treatment, CLP represents CG group, MLP represents MG group. (D) The PCA analysis of different treatment. E Quantification of protein expression expressed as Log2 Fold Charge present as volcano plot. The DEPs were statistically analyzed by T-test and P < 0.05 was considered significant, P < 0.01 was considered highly significant. F Cluster analysis of different groups presents as heatmap. G Enrichment analysis of DEPs using KEGG database to annotate show in bubble chart. H Enrichment analysis of DEPs using GO database to annotate show in bar chart. I Heatmap showing Ferroptosis related DEPs expression after Z-score normalization between CG and MG. Error bars are standard deviation (SD) (n = 3). Statistical analysis was done using one-way ANOVA; *, P ≤ 0.05; **, P ≤ 0.001 comparing to CG.

Back to article page