Table 3 Primary and secondary outcomes over the intervention in per-protocol seta

From: Effects of Lactiplantibacillus plantarum on moderate dyslipidemia before medication involving gut microbiota and host genetics

Outcome

Group

Pb

LP group

PLA group

Group

Time

Group × Time

LDL-C, mmol/L

  

0.995

< 0.001

0.041

Week 0

3.937 (0.568)

3.925 (0.625)

   

Week 6

4.143 (0.602)

4.033 (0.639)

   

Week 12

3.828 (0.640)

3.942 (0.624)

   

ΔWeek 6

0.195 (0.542)

0.111 (0.402)

   

ΔWeek 12

−0.100 (0.602)

0.018 (0.416)

   

TC, mmol/L

  

0.981

< 0.001

0.023

Week 0

5.808 (0.749)

5.789 (0.763)

   

Week 6

6.060 (0.764)

5.931 (0.766)

   

Week 12

5.688 (0.796)

5.828 (0.739)

   

ΔWeek 6

0.241 (0.624)

0.152 (0.473)

   

ΔWeek 12

−0.117 (0.703)

0.046 (0.510)

   

TG, mmol/L

  

0.424

0.006

0.394

Week 0

2.429 (0.807)

2.614 (1.547)

   

Week 6

2.726 (1.239)

2.742 (1.449)

   

Week 12

2.299 (0.896)

2.510 (0.920)

   

ΔWeek 6

0.286 (0.910)

0.232 (1.521)

   

ΔWeek 12

−0.087 (0.858)

-0.061 (1.306)

   

HDL-C, mmol/L

  

0.500

0.250

0.800

Week 0

1.083 (0.213)

1.072 (0.205)

   

Week 6

1.102 (0.215)

1.088 (0.189)

   

Week 12

1.122 (0.208)

1.090 (0.216)

   

ΔWeek 6

0.014 (0.118)

0.007 (0.126)

   

ΔWeek 12

0.019 (0.123)

0.022 (0.120)

   

INS, μU/mL

  

0.655

0.342

0.471

Week 0

12.121 (12.165)

11.180 (4.854)

   

Week 6

10.514 (7.268)

11.289 (5.438)

   

Week 12

11.161 (9.801)

11.594 (5.586)

   

ΔWeek 6

−1.009 (5.283)

0.060 (3.957)

   

ΔWeek 12

−0.799 (5.816)

0.343 (4.330)

   

GLU, mmol/L

  

0.580

0.153

0.177

Week 0

5.037 (0.332)

5.130 (0.518)

   

Week 6

5.106 (0.543)

5.129 (0.532)

   

Week 12

5.012 (0.462)

5.093 (0.548)

   

ΔWeek 6

0.055 (0.426)

-0.001 (0.431)

   

ΔWeek 12

−0.047 (0.365)

0.005 (0.422)

   

BMI, kg/m2

  

0.280

0.821

0.751

Week 0

25.617 (4.483)

24.786 (4.210)

   

Week 6

25.873 (6.458)

25.225 (5.106)

   

Week 12

26.358 (5.246)

24.995 (3.765)

   

ΔWeek 6

0.019 (4.246)

0.302 (3.923)

   

ΔWeek 12

0.325 (4.241)

0.032 (3.608)

   
  1. Data are mean (SD).
  2. aThe analysis was conducted in the per-protocol set (Participants without taking antibiotics and with compliance ≥ 85%). Week 0 (LP group: n = 55, PLA group: n = 59), week 6 (LP group: n = 48, PLA group: n = 55), week 12 (LP group: n = 47, PLA group: n = 54).
  3. bP values were determined by generalized estimating equation (GEE) adjusted for age, sex, baseline BMI, and corresponding baseline outcome measurement.
  4. BMI body mass index, GLU glucose, HDL-C high-density lipoprotein, INS insulin, LDL-C low-density lipoprotein cholesterol, LP Lactiplantibacillus plantarum, PLA placebo, TC total cholesterol, TG triglyceride.
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