Fig. 2: Data acquisition.

A board-certified pathologist selects 3 × 3 regions of interest (ROI), including tumor (\({\mathcal{T}}\)), stroma distant to the tumor (\({\mathcal{S}}\)), and tumor-stroma interface (\({\mathcal{T}}{/}{\mathcal{S}}\)) from breast cancer biopsy tissues for analysis.