Fig. 6: cMF-TVB simulation of the whole brain.

Whole-brain activity was simulated with cMF-TVB (one CRBL MF associated with each cerebellar cortical node and one WW associated with each deep cerebellar nucleus and cerebrum node). MAE across subjects for cMF-TVB (yellow) and TVB (blue) models, shown as line plots with dots representing individual data points. The shaded areas represent the SEM, indicating inter-subject variability. A simBOLD signals of DCN were extracted from whole-brain simulations performed with either cMF-TVB or TVB. For each subject, simBOLD was averaged over regions and compared to empBOLD by computing the subject-specific MAE for cMF-TVB and TVB. cMF-TVB improves DCN simulations for all the subjects remarkably (except for subject 4, where cMF-TVB and TVB are comparable). Overall, the MAE is significantly reduced when using cMF-TVB (Mann–Whitney p value < 0.001), showing that the inclusion of a region-specific model (i.e. CRBL MF) improves local dynamics compared to non-specific models (e.g. WW). B The subject-specific MAEs between empBOLD and simBOLD using cMF-TVB and TVB are also computed for the whole brain simulation. For all the subjects, cMF-TVB improves the simulation performance significantly (Mann–Whitney p value < 0.001), highlighting that region-specific models can also improve global dynamics.