Fig. 4: Bifurcation analysis for a detailed mammalian circadian model.
From: Low temperature abolishes human cellular circadian rhythm through Hopf bifurcation
A Preference of Hopf bifurcation of Kim–Forger model. To classify the type of bifurcation, nuclear Bmals expression was selected as a representative marker of circadian dynamics. We hypothesized that some of the 70 parameters of the Kim–Forger model depend on temperature. The probability of bifurcation type depending on the number of temperature-dependent parameters n is displayed. B Resonance of the Kim-Forger model under temperature cycles. We periodically altered the value of 10 distinct parameters (index #: 20, 56, 32, 2, 8, 64, 10, 21, 48, 53; see Supplementary Table 1) via switching the value of α between 1 (normal temp.) and 0.4 (below critical temp.).
