Fig. 6: Inference of master regulators and GRNs.
From: Mapping fusion-driven cell reprogramming through integrative single-cell computational frameworks
GRN analysis of co-cultured cells at Day 1 (A–C) and Day 3 (D–F). A UMAP visualization of Fusion hybrid, mMSC, and mHL1 cells at Day 1, with a list of non-overlapping master regulator TFs identified for each. B GRNs for selected master regulator TFs at Day 1. C Heatmap showing the top 10 RSS for master regulator TFs in Fusion hybrid, mMSC, and mHL1 cells (based on annotation) and in Clustree-defined clusters at Day 1. D UMAP visualization of mHL1-hybrid, mMSC-hybrid, mHL1, and mMSC cells at Day 3, with a list of non-overlapping master regulator TFs. E GRNs for selected master regulator TFs at Day 3. F Heatmap showing the top 10 RSS for master regulator TFs in the four cell populations (based on annotation) and in Clustree-defined clusters at Day 3.
