Fig. 2: Cell culture profiles at early passage (EP) and late passage (LP). | npj Systems Biology and Applications

Fig. 2: Cell culture profiles at early passage (EP) and late passage (LP).

From: Exploring CHO cell stability during prolonged passaging via eXplainable AI driven flux balance analysis

Fig. 2: Cell culture profiles at early passage (EP) and late passage (LP).

a Schematic of the long-term passaging and banking schedule with asterisks (*) on sampling points. b–i Comparison between early passage (EP; P10 and P12, red symbols/lines/bars) and late passage (LP; P26 and P28, blue symbols/lines/bars) cultures showing: b, c Viable cell density (VCD) and maximum VCD; d, e IgG titer and maximum IgG titer; f Glucose concentration; g Cell viability; h, i Lactate and ammonia concentration profiles. (Partial elements created with BioRender.com).

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