Fig. 3: Antibody functionality. | npj Vaccines

Fig. 3: Antibody functionality.

From: Inactivated rabies-based Lassa fever virus vaccine candidate LASSARAB protects nonhuman primates from lethal disease

Fig. 3

Assays measuring neutralizing and non-neutralizing antibody functions. a Pseudotype virus neutralization assay (VNA) for LASV with sera from immunized NHPs and human monoclonal anti-LASV-GPC antibody 37.7H as a positive control. Error bars represent standard deviation. b Antibody-dependent cellular cytotoxicity (ADCC) assay for LASV with sera from immunized NHPs. Error bars represent the standard error of the mean. c Rapid fluorescent focus inhibition test (RFFIT) to measure neutralizing antibodies against RABV (strain CVS-11). Neutralizing titers are represented as international units per mL (IU/mL). 0.5 IU/mL, the WHO threshold suggestive of protection, is indicated by the dotted line. NC negative control, ns not significant.

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